Arthonia ligniariella is reported for the first time from eastern North America based on a collection growing on lignum in North Carolina, U.S.A. Biatora appalachensis, an Appalachian endemic, is shown to be widespread throughout the Appalachian Mountains, primarily at high elevations. The only report of Fellhanera parvula from North America (Tennessee, U.S.A.) is considered to be F. bouteillei. Fellhanera subtilis, previously reported in North America from the Pacific Northwest, is reported for the first time from eastern North America (southern Appalachian Mountains). Gyalideopsis mexicana, previously reported in North America from the Yukon, Canada and New Mexico, U.S.A. is newly reported from eastern North America (southern Appalachian Mountains, North Carolina, U.S.A.). Lepra ouahensis, a sorediate species with lichexanthone and stictic acid, is reported from disjunct areas of the southern Appalachian Mountains and the Southeastern Coastal Plain. Its distribution is compared to the lichexanthone producing chemotypes of L. trachythallina and Varicellaria velata. Rockefellera crossophylla, a rare species considered extinct in Pennsylvania, U.S.A. is reported to be extant in that state. Psoronactis dilleniana is newly reported from North America from high elevations of the central and southern Appalachian Mountains (North Carolina and Virginia U.S.A.). Xenonectriella streimannii is newly reported for North America based on a collection found growing on Anaptychia palmulata in Georgia, U.S.A.