At the Cheever Mine, located in the eastern Adirondack Mountains of the Mesoproterozoic Grenville Province, iron oxide-apatite ore forms a narrow (\<3 m) sheet cross-cutting metasomatically altered, magnetite-bearing, albite-rich leucogranitic host rocks of the Lyon Mountain Granite suite. Zircon from the ore and five samples of country rock were dated by Laser Ablation-Multi-Collector-Inductively Coupled Plasma-Mass Spectrometry. The ore yielded a Concordia age of 1033.6 \textpm 2.9 Ma while three samples of host rock yielded ages of 1036.3 \textpm 2.9, 1040 \textpm 11, and 1043.9 \textpm 4.1 Ma. Two additional samples of host rock yielded older ages of 1059.6 \textpm 3.4 and 1066.0 \textpm 6.3 Ma and contain zircon xenocrystic cores with ²⁰⁷Pb/²⁰⁶Pb ages up to 1242 Ma. The zircons analyzed, including those separated from the ore, have characteristics typically associated with an igneous origin including size, shape, inclusions, oscillatory zoning, typical chondrite-normalized REE patterns, U contents, and U/Th ratios. This data establishes the age of the ore and alteration and a temporal, and likely genetic, connection between the ore and members of the Lyon Mountain Granite suite. A model invoking melting of Shawinigan country rocks, magmatic differentiation, and long-lived magmatic and metasomatic input along extensional fault conduits is proposed for the ore’s genesis. At the Cheever Mine, magmatic hydrothermal fluids and/or post-intrusion alteration appears not to have had a major impact on zircon, which preserves original U-Pb systematics.