The histories of maize utilization in eastern North America have been substantially revised recently, primarily because of the analysis of charred cooking residues encrusted on pottery. A multifaceted research strategy of bulk δ¹³C assays coupled with accelerator mass spectrometry radiocarbon data and microbotanical evidence can yield coherent regional maize use histories. Bulk δ¹³C assay interpretation complications include (1) variations among vessels by site, (2) a potential for false negatives, and (3) a wide range of variation potentially present for any given time period. Regional histories using this approach can be quite variable without appropriate use of multiple lines of evidence.